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5.1.08

How to remember the Coagulation Cascade

to memorize the coagulation cascade, devised by DR. Barone, kaplan path instructor (not in his kaplan video path lectures)

here it how it goes:

8 5
12--11--9--10--2--1
7

ok this is how it is:

-just go in order, factor 12(hageman factor), is followed by factor 11.
-naturally factor 10 should be followed by 11, but not in this case, cause 10 is special. It is number 10 on scale of 1 to 10, so it's special. 10 will not follow the order
-if 10 doesnt follow, then next in line is 9 so put factor 9 next to factor 11.
-now your factor 10 says that I wanna join the party. so put factor 10 next to 9
-factor 7 is lucky (lucky 7), so he is gonna go beloooowww factor 10 (that lucky number 7)
-what about factor 3, 4 and 6
just remember this song
3, 4,6 don't exis
3,4,6 don't exis
-put factor 8, up there between 9 and 10
-since 5 is also being outta place, put him also in the next position, which is between 10 and 2
-by the way after 10, the only factor that remains in order is 2
-naturally 1 should be after 2 also

now; what I'm about to tell you is kinda hard to draw in here, so I'll tell you how and you draw it yourself or at least imagine it:
-draw a line from 7 all the way to 10, and continue the line by making a right turn going to 2 and 1. If you notice you just drew a sided L. similar to shape of a gun.
Associate WARfarin with this gun (war for gun), so warfarin affect factors 7,10,2, 1 which is Extrinsic factor.

-draw a straight line from 12 till factor 1, and now you got the Intrinsic factors, associated with the other drug, which has to be PTT. Works pretty good so far.

Now remember, Warfarin, associated with Extrinsic pathway affects PT and heparin associated with Intrinsic factor, affects PTT (memory aid, pt is shorter in letters so it affects the shorter numbers of coag. factors. PTT being longer, affects the longer, intrinsic factors.

-now, draw a cros. Horizontal part is from 9 to 2.
Vertical part if from 10 down to 7
so you get

9-10-2
7

This cross is your Vit K dependent factors.

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